2Division of Hematology/Oncology and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CAFind articles by
1Genetic Epidemiology Research Institute and Department of Epidemiology, University of California Irvine, Irvine, CAFind articles by
The department of preventive medicine is at the Keck School of Medicine and the Norris Comprehensive Cancer Center is at the University of Southern California in Los Angeles, California.
1Genetic Epidemiology Research Institute and Department of Epidemiology, University of California Irvine, Irvine, CAFind articles by
The department of preventive medicine is at the Keck School of Medicine and the Norris Comprehensive Cancer Center is at the University of Southern California in Los Angeles, California.
The department of preventive medicine is at the Keck School of Medicine and the Norris Comprehensive Cancer Center is at the University of Southern California in Los Angeles, California.
1Genetic Epidemiology Research Institute and Department of Epidemiology, University of California Irvine, Irvine, CAFind articles by
Colorectal cancer (CRC) patients who eat less meat and take non-steroidal anti-inflammatory drugs (NSAIDs) regularly have a lower risk of dying. This study looked at the link between women in the California Teachers Study (CTS) cohort who normally ate meat before they were diagnosed with CRC and their death from that cancer. It also looked at whether women who normally ate meat change the link between NSAID use and CRC-specific death. Women who joined CTS in 1995–1996 without having a history of CRC and were later diagnosed with it during follow-up until December 2007 were eligible to be included. Self-administered questionnaires were used to find out how much and how often people ate meat, as well as how often and how much they took in NSAIDs (aspirin or ibuprofen). Vital status and cause of death were determined by linkage with mortality files. Some special models called multivariable Cox proportional hazards regression models were used to find the death risk ratios (HR) and 95% confidence intervals (CI). Pre-diagnosis meat consumption was not linked to death from colorectal cancer in a group of 704 patients (and 201 deaths) when comparing those in the lowest meat consumption tier (0–5). 4 medium-size servings/week) to those with higher consumption. Regular NSAID use (1–3 times/week, 4–6 times/week, daily) vs. none was associated with decreased CRC-specific mortality among patients in the lowest meat consumption tertile (HR=0. 22, 95% CI 0. 06–0. 82), but not among patients in the higher meat intake tertiles. The lower risk of death seen before in female CRC patients who took NSAIDs regularly was only seen in those who said they didn’t eat much meat before their diagnosis. These findings have implications for CRC survivorship and tertiary CRC prevention.
There are a lot of people in the US who have colorectal cancer (CRC). In 2009, there were an estimated 146,970 new cases and 49,920 deaths (1). Every year for the past ten years, progress has been made in both early detection and screening for CRC. As a result, a large group of people who have survived CRC has grown, bringing attention to how important it is to figure out what factors affect survival and come up with ways to lower the risk of death after a CRC diagnosis. Accordingly, diet and lifestyle factors have become increasingly active areas of CRC survivorship research.
Even though there is a long history of experiments, epidemiological studies, clinical trials (8, 9), and other types of research that have looked at how NSAIDs can stop CRC from growing, not many studies have looked at how NSAID use before or after diagnosis affects survival in CRC patients (10, 11). Recently, regular or long-term use of NSAIDs before diagnosis was linked to a lower risk of death from CRC in female CRC patients from the California Teachers Study (CTS) cohort (12), and aspirin use after diagnosis was linked to a similar lower risk of death among stage I–III colon cancer patients (13)
A prospective study of stage III colon cancer patients who had previously been enrolled in an adjuvant chemotherapy trial provided strong evidence that eating habits affect the outcome of CRC (14) High consumption of a Western dietary pattern (i. e. A diet high in meat, fat, refined grains, and dessert was linked to a shorter time between recurrences and a shorter overall survival rate. Members of our group showed that among CRC patients in a different group, those who ate the most meat had a lower overall survival rate than those who ate less meat. This was especially true for patients who had a first-degree relative with CRC (15).
A diet comprised of low meat consumption and regular NSAID use may influence survival after CRC diagnosis. There may be biological links between eating meat and using NSAIDs that affect the development of colorectal cancer, such as changes in polyamine metabolism (15–17). Before, to see if the effects of NSAIDs and diet-based polyamine-inhibitory experiments on mice would work in humans, some members of our group looked into them using data from the UC Irvine Gene Environment Study of Colorectal Cancer. A significant survival benefit was seen for familial CRC patients who said they regularly used NSAIDs and ate little meat compared to those who said they rarely used NSAIDs and ate a lot of meat. However, the analysis was limited by the small sample size (18). So, the purpose of this study was to find out if the positive effects of pre-diagnosis NSAIDs on CRC-specific mortality seen in patients from the CTS are only seen in those who said they didn’t eat much meat before the diagnosis.
The CTS is a group of future female public school teachers and administrators who are or were members of the California State Teachers Retirement System when the study began in 1995 (19). A total of 133,479 women comprise the CTS cohort. These institutions have given their permission for the CTS to happen and for the data analysis. They are the State of California, the University of Southern California, the University of California at Irvine, the Northern California Cancer Center, and the City of Hope National Medical Center.
To find incident invasive CRCs that happened during follow-up of the CTS, we first made a list of all the women who were eligible. We then left out women who: 1) did not get a CRC diagnosis as the first (or only) invasive cancer diagnosis during the follow-up period (n=132,721); 2) did not have information on a family history of CRC (n=26); 3) did not have information on how often they took NSAIDs (n=20); and 4) did not report how much meat they ate (n=8). The final group was made up of 704 people with CRC: 483 had colon cancer, 188 had rectal cancer, and 33 had large bowel cancer from an unknown site.
Ibuprofen is a common over-the-counter medication used to relieve pain, reduce fever, and decrease inflammation. It works by blocking the production of prostaglandins, hormones that promote inflammation, pain, and fever. While ibuprofen is generally safe when used as directed, it can cause side effects like stomach upset, bleeding, and kidney problems in some people. This leads many ibuprofen users to wonder if certain foods need to be avoided while taking this medication. One question that comes up is whether or not pork is safe to eat with ibuprofen.
How Ibuprofen Affects the Body
To understand if there are any dietary restrictions with ibuprofen, it helps to know how this drug affects the body. Here are some of the main ways ibuprofen works
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Reduces Production of Prostaglandins – Prostaglandins sensitize nerve endings and make you feel pain. Ibuprofen blocks enzymes called cyclooxygenase-1 and cyclooxygenase-2 that make prostaglandins.
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Inhibits Platelet Aggregation – Platelets are blood cells involved in clotting. Ibuprofen makes platelets less sticky, leading to a reduced ability to form clots.
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Constricts Blood Vessels – Ibuprofen causes blood vessels to narrow slightly. This reduces inflammation but can also increase blood pressure.
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Irritates Stomach Lining – Ibuprofen can damage the protective mucus layer in the stomach, allowing stomach acid to irritate the tissue underneath. This can lead to ulcers.
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Strains the Kidneys – Ibuprofen forces the kidneys to work harder to filter it out of the bloodstream. Over time, this can impair kidney function.
Does Ibuprofen Interact with Certain Foods?
Some medications can interact with specific foods, increasing side effects or reducing effectiveness. However there are no known food interactions with ibuprofen.
Ibuprofen is absorbed quickly on an empty stomach Taking it with food can slow the rate of absorption but does not alter the total amount absorbed. So ibuprofen can be taken with or without food
While ibuprofen does not directly interact with any foods, its gastrointestinal side effects mean it is best to avoid foods that could further irritate the digestive system. These include:
- Spicy, highly acidic, or very fatty foods – can aggravate the stomach lining
- Alcohol – increases risk of stomach bleeding
- Salty foods – may cause fluid retention
Other than avoiding foods that could worsen stomach upset or bleeding, there are no dietary restrictions with ibuprofen.
Is Pork Safe to Eat While Taking Ibuprofen?
There is no evidence that eating pork specifically would cause issues when taking ibuprofen. Pork is not known to interact with ibuprofen or increase its side effects.
However, certain preparations of pork may irritate the stomach:
- Fatty pork like bacon or sausage – high fat content could irritate the stomach
- Heavily spiced or smoked pork – may aggravate digestive system
- Processed pork like ham or lunchmeat – high sodium could cause fluid retention
To minimize gastrointestinal side effects, it would be best to avoid heavily processed or fatty pork products. But lean, mildly seasoned pork such as:
- Pork tenderloin
- Boneless pork chops
- Lean ham steak
- Canadian bacon
Would likely be fine for most people taking ibuprofen. The key is moderation. Sticking to 3-4 ounce portions of lean pork a couple times per week is unlikely to cause issues.
Those already experiencing ibuprofen-related digestive problems may want to avoid pork temporarily until symptoms resolve. And people with certain conditions like GERD, ulcers, or kidney disease should be especially cautious with pork and discuss diet with their doctor.
Other Tips for Taking Ibuprofen
To further reduce side effects when taking ibuprofen:
- Take the lowest effective dose for the shortest duration needed
- Avoid drinking alcohol
- Stay well hydrated
- Limit salty foods
- Include gut-friendly foods like yogurt, bananas, and oatmeal
- Take ibuprofen with food to minimize stomach irritation
Being mindful of portions of fatty or heavily seasoned foods, including pork, is also recommended. But otherwise, moderate intake of lean pork does not need to be avoided solely due to taking ibuprofen.
Of course, it’s always best to consult your healthcare provider with any medication-related concerns. But generally, consuming lean pork in moderation can be safe for most people taking ibuprofen as directed. Focus on listening to your body and discontinue any foods that seem to worsen side effects.
Case Ascertainment and Follow-up
Detections of invasive cancer of the colon and rectum (ICD-O topography codes C18) 0–18. 9, C19. 9, and C20. 9) were identified through annual linkages with the California Cancer Registry (CCR). The California Cancer Registry (CCR) gets reports on more than 98% of all cancer diagnoses in the state (20). According to the Surveillance, Epidemiology, and End Results (SEER) definition for summary stage, tumors were put into three groups at the time of presentation: local, regional, and advanced. Treatment during the first course of therapy was ascertained using available CCR data.
Regular connections with California state death records and the Social Security Death Master File made it possible to find out who had died among the CTS participants. Cause of death was provided on the California files and through linkages with the National Death Index. Follow-up of eligible CRC patients was calculated from the date of diagnosis until death, or December 31, 2007. The cause of death was recorded based on the criteria used by the International Classification of Diseases at the time of death, as explained earlier (22). Patients who died of something other than CRC were not included, and neither were patients who lived until the end of the follow-up period. Overall there were 302 deaths (42. 9 percent of all patients (20207 colon, 69 rectal, and 26 large bowel unspecified), and death from CRC happened in 20201% of those patients (66 5%) CRC patients (134-colon, 49-rectum, and 18-large bowel unspecified). Additional deaths were attributed to heart disease (10. 6%), other malignancies (9. 6%), chronic obstructive pulmonary disease (2. 3%), and other etiologies (11%).
Assessment of Dietary Intake and Meat Consumption
Patients self-reported their food intake using a validated 100-item NCI-Block food-frequency questionnaire (FFQ) that was given at the start of the study (cohort entry). They were asked to describe their normal eating habits from the year before they joined the cohort (23) Micronutrient information, daily fiber intake, and daily energy intake were all figured out from the answers people gave on the FFQ (24) This study looked at the following types of meat: hot dogs, liver (including chicken livers), lunch meat (such as ham, bologna, and other lunch meats made with or without turkey), other meat soups, pork (such as pork chops and pork roast), sausage, chicken or turkey, chicken stew or mixed chicken dish, fried chicken, fried fish, oysters, shellfish, tuna, and beef roast or beef steaks or sandwiches. The number of medium-sized servings/week for each meat item was found by multiplying the number of servings/week by the estimated serving size. The options were “never,” “once a month,” “2–3 times a month,” “once a week,” “2 times a week,” “3–4 times a week,” “5–6 times a week,” and “every day.” 5 for small, 1. 0 for medium, and 1. 5 for large). CRC patients were divided into tertiles based on their consumption of medium-sized servings: Tertile 1, 0. 0–5. 39 servings/week; Tertile 2, 5. 40–9. 14 servings/week; Tertile 3, 9. 15–29. 52 servings/week.
What They Don’t Tell You About IBUPROFEN- Affects Healing?
FAQ
What not to eat with ibuprofen?
What Cannot be taken with ibuprofen?
Does ibuprofen interact with any foods?
What foods should you eat while taking NSAIDs?
Can ibuprofen be taken with food?
Overall, changing from taking NSAIDs like ibuprofen with food to just water – unless there is stomach upset – may improve pain relief and is very unlikely to harm people who take the drug occasionally and as directed. Those who use ibuprofen and other NSAIDs for chronic pain relief, however, should consult their doctor about how best to take it.
Can one eat pork?
A cooked, medium pork cutlet or steak provides 239 calories, 34 grams protein, 10 grams fat, 4 grams saturated fat, 697 milligrams sodium, and 0 grams carbohydrate, if you eat only the lean part of the steak. Pork contains many of the micronutrients (vitamins and minerals) found in beef and it is high in protein, but can be lower in fat than beef—depending on cut and preparation. Meat from any kind of mammal, including pork, can cause an allergic reaction (and some people who are allergic to mammalian meat also react to poultry).
Can ibuprofen be taken with milk?
For this reason, ibuprofen (and other NSAIDs) can be consumed with a meal or accompanied by milk to avoid stomach discomfort. If you’re using ibuprofen regularly, establish a consistent daily schedule.
Can you take ibuprofen with a spoon?
Do not use a kitchen spoon, as it will not measure the right amount. Take ibuprofen tablets, capsules, granules or liquid with a meal or snack, or with a drink of milk. It will be less likely to upset your stomach. If you take it just after food, ibuprofen may take longer to start working.